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Published on: May 6, 2015
Strategies to develop vaccines of pediatric interest
Susanna Esposito1, Nicola Principi1
1a Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation , Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico , Milan , Italy.
Insights
New pediatric vaccines against serious childhood diseases like pneumococcal disease and respiratory syncytial virus are in development. Advances in immunology and technology aid rational vaccine design, with future clinical trials needed for licensing.
Area of Science:
- Pediatric Vaccinology
- Immunology
- Infectious Disease Prevention
Background:
- The success of current vaccines fuels interest in developing new ones.
- Significant childhood morbidity and mortality are associated with preventable infectious diseases.
Purpose of the Study:
- To review key pediatric vaccines currently under development.
- To highlight advances in immunology and technology enabling rational vaccine design.
Main Methods:
- Review of emerging vaccines for pediatric use.
- Analysis of scientific advancements in immunology and vaccine target structural biology.
Main Results:
- Detailed analysis of novel pneumococcal, Group B Streptococcus, Staphylococcus aureus, and respiratory syncytial virus vaccines.
- Identification of key immunological and technological tools guiding vaccine development.
Conclusions:
- Several promising pediatric vaccines are in development, potentially reducing severe childhood diseases.
- Further animal studies and clinical trials in children are essential before new vaccines can be licensed.
Introduction:
The success of the vaccines available on the market has significantly increased interest in vaccine development. Areas covered: The main aim of this paper is to discuss the most important vaccines of pediatric interest that are currently being developed. New pneumococcal vaccines and vaccines against group B Streptococcus, Staphylococcus aureus and respiratory syncytial virus are analyzed in detail. Expert commentary: Advances in understanding human immunology, including human monoclonal antibody identification, sequencing technology, and the ability to solve atomic level structures of vaccine targets have provided tools to guide the rational design of future vaccines. It is likely that some of these vaccines will reach the market in the future and will thus partially contribute to the prevention of very severe diseases that significantly affect the morbidity and mortality of children. However, further studies in animals and several clinical trials in children must be performed before new vaccines become licensed.
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