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Identity Crisis: CD301b(+) Mononuclear Phagocytes Blur the M1-M2 Macrophage Line
Nelson H Knudsen1, Chih-Hao Lee1
1Department of Genetics and Complex Diseases, Division of Biological Sciences, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA.
Abstract:
Obesity shifts the immune phenotype from M2 macrophage polarization to M1, which causes metabolic dysfunction. In this issue of Immunity, Kumamoto et al. (2016) identify a tissue-resident mononuclear phagocyte population that promotes weight gain and glucose intolerance but are defined by the M2 marker CD301b.
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