Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Duration of Initial Viremia Modulates Functional Properties of HIV-specific T Cell Receptors.

Research square·2026

Same author

Duration of Initial Viremia Modulates Functional Properties of HIV-specific T Cell Receptors.

bioRxiv : the preprint server for biology·2026

Same author

CD8<sup>+</sup> T cell stemness precedes post-intervention control of HIV viraemia.

Nature·2025

Same author

CD8<sup>+</sup> T cell recall cytotoxicity during chronic treated HIV-1 infection is associated with limited reservoir size and activity.

medRxiv : the preprint server for health sciences·2025

Same author

Guidelines for T cell nomenclature.

Nature reviews. Immunology·2025

Same author

Bayesian estimation of HIV acquisition dates for prevention trials.

mBio·2025

Search research articles

Related Experiment Video

Updated: Mar 14, 2026

Studying Interactions between Myeloid Cells and CAR T Cells In Vitro and In Vivo

Studying Interactions between Myeloid Cells and CAR T Cells In Vitro and In Vivo

Published on: July 25, 2025

CD8(+) T Cells and cART: A Dynamic Duo?

Gaurav D Gaiha¹, Bruce D Walker²

¹Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.

|September 23, 2016

Summary

A new macaque study indicates that CD8(+) T cells may help suppress HIV-1. This finding suggests a previously unrecognized role for these immune cells during antiretroviral therapy.

More Related Videos

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

Related Experiment Videos

Last Updated: Mar 14, 2026

Studying Interactions between Myeloid Cells and CAR T Cells In Vitro and In Vivo

Studying Interactions between Myeloid Cells and CAR T Cells In Vitro and In Vivo

Published on: July 25, 2025

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

Area of Science:

Immunology
Virology
Primate Studies

Background:

Human immunodeficiency virus type 1 (HIV-1) infection remains a global health challenge.
Antiretroviral therapy (ART) is the cornerstone of HIV-1 management, but viral suppression can be incomplete in some cases.
The precise mechanisms of viral control during ART are not fully understood.

Purpose of the Study:

To investigate the potential role of CD8(+) T cells in controlling HIV-1 replication during ART.
To explore previously unrecognized functions of CD8(+) T cells in the context of viral suppression.

Main Methods:

The study utilized a macaque model of HIV-1 infection.
Researchers analyzed the activity and function of CD8(+) T cells in animals undergoing ART.

Main Results:

Results suggest that CD8(+) T cells may exert a suppressive effect on HIV-1.
Evidence indicates a potential role for these cells in limiting viral load during treatment.

Conclusions:

CD8(+) T cells might play a significant, previously unrecognized role in suppressing HIV-1.
These findings could inform future therapeutic strategies aimed at enhancing viral control during ART.