Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

4.1K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
4.1K
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

4.6K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
4.6K
Chemical Synapses01:26

Chemical Synapses

6.8K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
6.8K
Chemical Synapses01:26

Chemical Synapses

12.3K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
12.3K
Long-term Potentiation01:35

Long-term Potentiation

59.2K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
59.2K
Long-term Potentiation01:25

Long-term Potentiation

3.8K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Centrally expressed Cav3.2 T-type calcium channel is critical for the initiation and maintenance of neuropathic pain.

eLife·2022
Same author

Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures.

Brain : a journal of neurology·2020
Same author

Editorial-Methods and models in sleep research.

Journal of neuroscience methods·2018
Same author

[New light shed on thalamocortical excitability in absence epilepsy].

Medecine sciences : M/S·2018
Same author

Layer 2/3 Pyramidal Neurons Control the Gain of Cortical Output.

Cell reports·2018
Same author

Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures.

Nature neuroscience·2018
Same journal

mTORC2-Na<sub>v</sub>1.2 signaling drives early hyperexcitability in Alzheimer's disease mouse model.

Channels (Austin, Tex.)·2026
Same journal

Role for TREK-1 as a polymodal sensor and regulator of cell activity.

Channels (Austin, Tex.)·2026
Same journal

Quantitative analysis of trafficking defects induced by heterozygous expression of hERG voltage sensor domain variants.

Channels (Austin, Tex.)·2026
Same journal

Transient receptor potential canonical (TRPC) channels in diabetes and associated complications.

Channels (Austin, Tex.)·2026
Same journal

Transient receptor potential channels in <i>Flaviviridae</i> infection: A comprehensive review.

Channels (Austin, Tex.)·2026
Same journal

TRPV4 mediates macrophage polarization involved in inflammatory root resorption induced by mechanical pressure.

Channels (Austin, Tex.)·2026
See all related articles

Related Experiment Video

Updated: Mar 14, 2026

Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals
08:38

Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals

Published on: May 25, 2011

16.1K

T-type calcium channels in synaptic plasticity.

Nathalie Leresche1, Régis C Lambert1

  • 1a Sorbonne Universités, Université Pierre et Marie Curie (UPMC) UM119, CNRS UMR8246, INSERM U1130, Neuroscience Paris Seine (NPS) , Paris , France.

Channels (Austin, Tex.)
|September 23, 2016
PubMed
Summary
This summary is machine-generated.

T-type calcium channels, once overlooked, are now recognized for their role in synaptic plasticity. New research highlights their involvement in various synaptic mechanisms and their importance in the neocortex and thalamus.

Keywords:
Cav3.1Cav3.2Cav3.3long-term depressionlong-term potentiationneuronsynapsethalamusvisual system

More Related Videos

Two-photon Calcium Imaging in Neuronal Dendrites in Brain Slices
10:35

Two-photon Calcium Imaging in Neuronal Dendrites in Brain Slices

Published on: March 15, 2018

11.7K
Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

14.8K

Related Experiment Videos

Last Updated: Mar 14, 2026

Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals
08:38

Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals

Published on: May 25, 2011

16.1K
Two-photon Calcium Imaging in Neuronal Dendrites in Brain Slices
10:35

Two-photon Calcium Imaging in Neuronal Dendrites in Brain Slices

Published on: March 15, 2018

11.7K
Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

14.8K

Area of Science:

  • Neuroscience
  • Synaptic Plasticity
  • Ion Channels

Background:

  • T-type calcium channels' role in synaptic plasticity is understudied due to a lack of specific antagonists.
  • Recent advancements in pharmacological and genetic tools have enabled new investigations.

Purpose of the Study:

  • To review the emerging evidence for T-type calcium channel involvement in synaptic plasticity.
  • To discuss the molecular partners and subcellular localization of T-type channels in plasticity.
  • To illustrate the functional significance of T-type channel-dependent plasticity in brain regions like the neocortex and thalamus.

Main Methods:

  • Review of existing scientific literature.
  • Analysis of studies employing new pharmacological and genetic tools.
  • Examination of homo- and hetero-synaptic plasticity mechanisms.

Main Results:

  • T-type calcium channels participate in diverse homo- and hetero-synaptic plasticity mechanisms.
  • These channels interact with various molecular partners and mediate pre- and post-synaptic modifications.
  • Evidence suggests specific subcellular localization of T-type channels and their partners, allowing for distinct plasticity pathways.

Conclusions:

  • T-type calcium channels play a significant role in synaptic plasticity.
  • Their involvement spans multiple molecular and cellular mechanisms.
  • T-channel dependent synaptic plasticity is functionally important in the neocortex and thalamus.