Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Myocarditis I: Introduction

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...

Myasthenia Gravis: Overview and Treatment

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...

Disorders of the Skeletal Muscle

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...

Myasthenia Gravis: Diagnostic Tests

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Lymphoma-associated dysimmune polyneuropathies.

Journal of the neurological sciences·2015

Same author

A review on the association between inflammatory myopathies and vaccination.

Autoimmunity reviews·2013

Same author

A literature review on optic neuritis following vaccination against virus infections.

Autoimmunity reviews·2013

Same author

A review of the use of biological agents for chronic inflammatory demyelinating polyradiculoneuropathy.

Journal of the neurological sciences·2013

Same author

Posterior reversible encephalopathy syndrome (PRES) after granulocyte-colony stimulating factor (G-CSF) therapy: a report of 2 cases.

Journal of the neurological sciences·2012

Same author

Targeted immunotherapy trials for idiopathic inflammatory myopathies.

Journal of neurology·2012

Search research articles

Related Experiment Video

Updated: Mar 14, 2026

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

Inflammatory myopathies and lymphoma.

Joerg-Patrick Stübgen¹

¹Department of Neurology, Weill Cornell Medical College/New York Presbyterian Hospital, 525 East 68th Street, New York, NY 10065-4885, USA.

Journal of the Neurological Sciences

|September 23, 2016

Summary

Inflammatory myopathies, immune-mediated muscle diseases, are linked to lymphoma, a lymphatic cancer. Immune dysregulation is suspected in lymphoma development among patients with inflammatory myopathies.

Keywords:

Autoimmunity Dermatomyositis Lymphoma Polymyositis

More Related Videos

Immunolabelling Myofiber Degeneration in Muscle Biopsies

Immunolabelling Myofiber Degeneration in Muscle Biopsies

Published on: December 5, 2019

Related Experiment Videos

Last Updated: Mar 14, 2026

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

Immunolabelling Myofiber Degeneration in Muscle Biopsies

Immunolabelling Myofiber Degeneration in Muscle Biopsies

Published on: December 5, 2019

Area of Science:

Immunology
Oncology
Rheumatology

Background:

Inflammatory myopathies are immune-mediated muscle diseases.
Lymphoma is a malignancy of the lymphatic system.
Autoimmune diseases and lymphoproliferative malignancies share a complex relationship.

Purpose of the Study:

To explore the relationship between inflammatory myopathies and lymphoma.
To understand the underlying immune mechanisms connecting these conditions.

Main Methods:

Review of existing literature on inflammatory myopathies and lymphoma.
Analysis of immune system dysregulation in autoimmune and lymphoproliferative disorders.

Main Results:

A causal link between inflammatory myopathies and lymphoma is not established.
Diagnosis of inflammatory myopathy often precedes lymphoma detection.
Immune dysregulation, chronic B-cell activation, and antigen stimulation are key risk factors for lymphoma in autoimmune patients.

Conclusions:

Immune dysregulation is presumed to drive lymphoma in inflammatory myopathy patients.
Chronic inflammation and B-cell activation are major lymphoma risk factors in autoimmunity.
Paraneoplastic phenomena or immunosuppressive therapy effects are potential alternative mechanisms.