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As discussed in previous lessons, strain energy in a material is the energy stored when it is elastically deformed, a concept crucial in materials science and mechanical engineering. This energy results from the internal work done against the cohesive forces within the material. When a material undergoes shearing stress and corresponding shearing strain, the strain energy density, which is the energy stored per unit volume, is calculated. Within the elastic limit, where the stress is...
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Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.
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The quantity that describes the deformation of a body under stress is known as strain. Strain is given as a fractional change in either length, volume, or geometry under tensile, volume (also known as bulk), or shear stress, respectively, and is a dimensionless quantity. The strain experienced by a body under tensile or compressive stress is called tensile or compressive strain, respectively. In contrast, the strain experienced under bulk stress and shear stress is known as volume and shear...
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Quantifying tissue viscoelasticity using optical coherence elastography and the Rayleigh wave model.

Zhaolong Han1, Manmohan Singh1, Salavat R Aglyamov2

  • 1University of Houston, Department of Biomedical Engineering, 3605 Cullen Boulevard, Houston, Texas 77204, United States.

Journal of Biomedical Optics
|September 23, 2016
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Summary
This summary is machine-generated.

This study shows that combining the Rayleigh wave model (RWM) with optical coherence elastography (OCE) can assess soft tissue viscoelasticity. This noninvasive technique accurately measures biomechanical properties, aiding in disease detection.

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Area of Science:

  • Biomedical Engineering
  • Biophysics
  • Materials Science

Background:

  • Assessing soft tissue viscoelasticity is crucial for disease diagnosis.
  • Noninvasive methods for quantifying biomechanical properties are highly sought after.
  • Optical Coherence Elastography (OCE) offers high-resolution imaging but requires robust models for quantitative analysis.

Purpose of the Study:

  • To demonstrate the feasibility of using the Rayleigh wave model (RWM) with optical coherence elastography (OCE) for soft tissue viscoelasticity assessment.
  • To validate the combined RWM-OCE method using phantoms and biological tissues.
  • To establish a noninvasive technique for quantifying biomechanical properties.

Main Methods:

  • Spectral decomposition of air-pulse induced elastic waves measured by OCE.
  • Application of the Rayleigh wave model (RWM) to dispersion curves for viscoelasticity quantification.
  • Validation using 10% gelatin phantoms with varying oil concentrations and chicken liver tissue.

Main Results:

  • Increased oil concentration in gelatin phantoms led to higher viscosity.
  • Chicken liver Young's modulus (E) estimated at 2.04±0.88 kPa and shear viscosity (η) at 1.20±0.13 Pa·s.
  • High correlation (R²=0.96±0.04) between RWM analytical solution and OCE-measured phased velocities.

Conclusions:

  • The combination of RWM and OCE is a feasible and promising method for noninvasively quantifying soft tissue biomechanical properties.
  • This technique has potential applications in disease detection through altered tissue viscoelasticity.
  • The RWM accurately models OCE-measured elastic wave propagation in soft tissues.