Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pudgy mouse rib deformities emanate from abnormal paravertebral longitudinal cartilage/bone accumulations.

Biology open·2024

Same author

Automated measurement of lamellar thickness in human bone using polarized light microscopy.

MethodsX·2023

Same author

Lamellar thickness measurements in control and osteogenesis imperfecta human bone, with development of a method of automated thickness averaging to simplify quantitation.

Matrix biology : journal of the International Society for Matrix Biology·2023

Same author

Histopathology of osteogenesis imperfecta bone. Supramolecular assessment of cells and matrices in the context of woven and lamellar bone formation using light, polarization and ultrastructural microscopy.

Bone reports·2021

Same author

Direct Reprogramming of Mouse Fibroblasts into Functional Osteoblasts.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2019

Same author

The Liberfarb syndrome, a multisystem disorder affecting eye, ear, bone, and brain development, is caused by a founder pathogenic variant in thePISD gene.

Genetics in medicine : official journal of the American College of Medical Genetics·2019

Same journal

Christopher Addison (1869-1951): Distinguished Anatomist and Politician.

Advances in anatomy, embryology, and cell biology·2026

Same journal

Surgical Contributions to Anatomical Knowledge.

Advances in anatomy, embryology, and cell biology·2026

Same journal

The Rise and Tragic Fall of Charles Averill MRCS (1796-1830), Gentleman Surgeon of Cheltenham.

Advances in anatomy, embryology, and cell biology·2026

Same journal

Richard Owen's Golgotha: Lancaster Castle and the Prisoner's Head that Rolled.

Advances in anatomy, embryology, and cell biology·2026

Same journal

Labiaplasty: Mind the Gap-How the Female Genital Cosmetic Surgery Industry Has Exposed Gaps in Modern Medical Anatomy Education.

Advances in anatomy, embryology, and cell biology·2026

Same journal

Trends Versus Transformative Tools Within Anatomy Education: The Case for Ultrasound.

Advances in anatomy, embryology, and cell biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 14, 2026

Demonstrating the Simplicity and In Situ Temperature Monitoring of the Mechanochemical Synthesis of Metal Chalcogenides Suitable for Thermoelectrics

Demonstrating the Simplicity and In Situ Temperature Monitoring of the Mechanochemical Synthesis of Metal Chalcogenides Suitable for Thermoelectrics

Published on: August 30, 2024

Materials and Methods.

Frederic Shapiro¹

¹Laboratory for the Study of Skeletal Disorders, Harvard Medical School, Boston, Massachusetts, USA.

Advances in Anatomy, Embryology, and Cell Biology

|September 23, 2016

Summary

This summary is machine-generated.

Pudgy mice (pu/pu) exhibit distinct physical traits at birth, including a shortened body and tail. This study investigated skeletal anomalies in these mice, comparing affected individuals to their unaffected littermates.

More Related Videos

Biomechanical Testing of Murine Tendons

Biomechanical Testing of Murine Tendons

Published on: October 15, 2019

Quasistatic Mechanical Testing for Computer-Aided Design and Manufacturing Occlusal Veneers Cemented to Milled Dentin Analog Material

Quasistatic Mechanical Testing for Computer-Aided Design and Manufacturing Occlusal Veneers Cemented to Milled Dentin Analog Material

Published on: December 20, 2024

Related Experiment Videos

Last Updated: Mar 14, 2026

Demonstrating the Simplicity and In Situ Temperature Monitoring of the Mechanochemical Synthesis of Metal Chalcogenides Suitable for Thermoelectrics

Demonstrating the Simplicity and In Situ Temperature Monitoring of the Mechanochemical Synthesis of Metal Chalcogenides Suitable for Thermoelectrics

Published on: August 30, 2024

Biomechanical Testing of Murine Tendons

Biomechanical Testing of Murine Tendons

Published on: October 15, 2019

Quasistatic Mechanical Testing for Computer-Aided Design and Manufacturing Occlusal Veneers Cemented to Milled Dentin Analog Material

Quasistatic Mechanical Testing for Computer-Aided Design and Manufacturing Occlusal Veneers Cemented to Milled Dentin Analog Material

Published on: December 20, 2024

Area of Science:

Developmental Biology
Genetics
Skeletal Biology

Background:

The pudgy mouse model (pu/pu) is characterized by specific physical manifestations at birth.
Heterozygous littermates (pu/+) serve as controls for affected pudgy mice.
Affected mice are identifiable by their reduced body length and shortened, twisted tail.

Purpose of the Study:

To investigate and characterize vertebral and rib anomalies in pudgy mice (pu/pu).
To compare skeletal development between affected pudgy mice and their unaffected littermates.
To analyze skeletal anomalies within litters containing affected siblings.

Main Methods:

Skeletal assessments of vertebral and rib structures were performed.
A cohort of 68 mice (37 affected, 31 unaffected) aged from late embryo to 3 months were analyzed.
Comparative analysis was conducted between affected mice, unaffected littermates, and within litters.

Main Results:

Affected pudgy mice (pu/pu) displayed significant vertebral and rib anomalies compared to non-affected siblings (pu/+).
Analysis of multiple litters allowed for intra-litter comparisons of skeletal defects.
The study identified specific patterns of skeletal malformations in the pudgy mouse model.

Conclusions:

Pudgy mice (pu/pu) serve as a valuable model for studying genetic influences on skeletal development.
The findings highlight the presence of significant rib and vertebral anomalies in this model.
Further research can elucidate the genetic mechanisms underlying these skeletal defects.