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Related Experiment Video

Updated: Mar 14, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
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Osteogenic Melanoma With Desmin Expression.

Flávia Trevisan1, Aline C Tregnago, Clóvis A Lopes Pinto

  • 1*Department of Dermatology, Hospital de Clinicas da UFPR, Curitiba, Brazil; Departments of †Anatomic Pathology, and ‡Skin Cancer, A. C. Camargo Cancer Center, São Paulo, Brazil.

The American Journal of Dermatopathology
|September 23, 2016
PubMed
Summary
This summary is machine-generated.

This study highlights a rare case of osteogenic melanoma in a patient's toe. Recognizing this rare melanoma subtype is crucial for accurate diagnosis and treatment.

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Area of Science:

  • Dermatopathology
  • Oncology
  • Skeletal Biology

Background:

  • Osteogenic differentiation is an uncommon phenomenon in melanoma, typically observed in acral lesions.
  • Melanomas with osteogenic features present diagnostic challenges due to their rarity.

Observation:

  • A case of osteogenic melanoma is presented in a 49-year-old woman with a subungual lesion on the left hallux.
  • The ulcerated lesion infiltrated the deep dermis but did not involve bone.

Findings:

  • Histopathology revealed atypical epithelioid and fusiform cells with osteoid matrix formation and focal mineralization.
  • Immunohistochemistry showed strong S-100 and desmin expression, with focal Melan-A, microphthalmia transcription factor, and HMB-45 positivity.
  • BRAF and NRAS gene mutations were absent.

Implications:

  • Accurate histologic recognition of osteogenic melanoma is essential for differential diagnosis.
  • Understanding the unique immunohistochemical profile aids in diagnosing this rare melanoma variant.
  • This case underscores the importance of considering rare presentations in melanoma diagnosis.