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[Recent progress in clinical research on pertussis].

Dan-Xia Wu1, Qiang Chen, Kun-Ling Shen

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Pertussis, a contagious respiratory illness, is re-emerging globally. This review focuses on updated pertussis diagnosis in older children and adults, crucial for effective prevention and treatment.

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Area of Science:

  • Public Health
  • Infectious Diseases
  • Epidemiology

Background:

  • Pertussis (whooping cough) is a highly contagious respiratory disease.
  • Despite high vaccination rates, pertussis re-emergence is a growing global concern over the last two decades.
  • A shift in pertussis epidemiology shows increased incidence in older children and adults, often with atypical symptoms.

Purpose of the Study:

  • To review recent advancements in pertussis research.
  • To focus on the diagnosis of pertussis, especially in older children and adults.
  • To aid in the improved prevention and treatment of pertussis.

Main Methods:

  • Literature review of recent research on pertussis.
  • Synthesis of information on epidemiology, clinical features, etiology, diagnosis, treatment, and prevention.
  • Emphasis on diagnostic challenges in non-infants.

Main Results:

  • Pertussis incidence is increasing in older populations.
  • Typical pertussis symptoms are often absent in adults and older children.
  • Current diagnostic criteria may miss pertussis cases in these demographics.

Conclusions:

  • Re-emerging pertussis requires updated diagnostic approaches, particularly for adults and older children.
  • Accurate diagnosis in all age groups is essential for effective control and treatment strategies.
  • Further research into pertussis in older populations is warranted.