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Related Experiment Video

Updated: Mar 14, 2026

Dissection of the Auditory Bulla in Postnatal Mice: Isolation of the Middle Ear Bones and Histological Analysis

Dissection of the Auditory Bulla in Postnatal Mice: Isolation of the Middle Ear Bones and Histological Analysis

Published on: January 4, 2017

Sorting nexin 9 (SNX9) is not essential for development and auditory function in mice.

Chengcheng Liu¹, Xiaoyan Zhai¹, Haibo Du¹

¹Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, Jinan, Shandong 250100, P. R. China.

|September 23, 2016

Summary

Sorting nexin 9 (SNX9) is crucial for actin regulation. However, Snx9 knockout mice show normal development and auditory function, indicating SNX9 is not essential for hearing.

Keywords:

SNX9 hair cells hearing inner ear knockout mice

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Last Updated: Mar 14, 2026

Dissection of the Auditory Bulla in Postnatal Mice: Isolation of the Middle Ear Bones and Histological Analysis

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Published on: January 4, 2017

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

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Published on: May 10, 2019

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Published on: March 18, 2013

Area of Science:

Cell biology
Molecular biology
Genetics

Background:

Sorting nexins (SNXs) are proteins involved in endocytosis and signaling.
Sorting nexin 9 (SNX9) coordinates actin polymerization with membrane dynamics.
SNX9 is expressed in mouse auditory hair cells and may regulate actin.

Purpose of the Study:

To investigate the physiological role of SNX9 in vivo.
To determine if SNX9 is essential for mouse development and auditory function.

Main Methods:

Generation of Snx9 knockout mice using homologous recombination.
Assessment of viability, fertility, morphology, and behavior.
Evaluation of auditory hair cell morphology and function, and hearing thresholds.

Main Results:

Snx9 knockout mice exhibited normal viability, fertility, and overall phenotype.
Auditory hair cell morphology and function remained unaffected in knockout mice.
Hearing thresholds were normal in Snx9-deficient mice.

Conclusions:

SNX9 is not essential for mouse development.
The absence of SNX9 does not impair auditory hair cell function or hearing.
These findings suggest SNX9 has a redundant or non-critical role in hearing and development in mice.