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Updated: Mar 14, 2026

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
Published on: October 31, 2010
Cost-effectiveness of implementing the chronic care model for HIV care in Uganda
Edward I Broughton1,2, Martin Muhire3, Esther Karamagi4
1R&E director, University Research Co., LLC.
Objective:
The chronic care model (CCM) is an integrated, population-based approach for treating those with chronic diseases that involves patient self-management, delivery system design and decision support for clinicians to ensure evidence-based care. We sought to determine effectiveness and cost-effectiveness of implementing the CCM for HIV care in Uganda.
Design:
This controlled, pre/post-intervention study used difference-in-differences analysis to evaluate effectiveness of the CCM to improve patient adherence to antiretroviral therapy (ART) and CD4 counts.
Setting:
One district hospital and two smaller facilities each in one intervention and one control district in Uganda.
Participants:
About 46 randomly sampled patients receiving HIV services at three control sites and 56 patients from three intervention sites.
Intervention:
Two group training sessions and monthly coaching visits from improvement experts over 1 year, implementing the CCM.
Main Outcome Measure(S):
Patient adherence to ART prescriptions (pill counts) and CD4 counts were measured at baseline and en dline.
Results:
The odds of increased CD4 in the intervention group was 3.2 times higher than controls (P = 0.022). Clinician-reported ART adherence was 60% (P = 0.001) higher in the intervention group. The intervention cost $11 740 and served 7016 patients ($1.67 per patient). Incremental cost-effectiveness ratios of the intervention compared to business-as-usual was $6.90 per additional patient with improved CD4 and $3.40 per additional ART patient with stable or improved adherence.
Conclusion:
For modest expenditure, it is possible to improve indicators of HIV care quality using the CCM. We recommended implementing the CCM in Uganda; it may be applicable in similar settings in other countries.
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