Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Residuals and Least-Squares Property01:11

Residuals and Least-Squares Property

9.7K
The vertical distance between the actual value of y and the estimated value of y. In other words, it measures the vertical distance between the actual data point and the predicted point on the line
If the observed data point lies above the line, the residual is positive, and the line underestimates the actual data value for y. If the observed data point lies below the line, the residual is negative, and the line overestimates the actual data value for y.
The process of fitting the best-fit...
9.7K
Vector Algebra: Method of Components01:08

Vector Algebra: Method of Components

20.4K
It is cumbersome to find the magnitudes of vectors using the parallelogram rule or using the graphical method to perform mathematical operations like addition, subtraction, and multiplication. There are two ways to circumvent this algebraic complexity. One way is to draw the vectors to scale, as in navigation, and read approximate vector lengths and angles (directions) from the graphs. The other way is to use the method of components.
In many applications, the magnitudes and directions of...
20.4K
Quadratic Models01:23

Quadratic Models

283
Quadratic models are mathematical representations used to describe relationships in which the rate of change changes at a constant rate. These models appear in a wide variety of natural and engineered systems, especially those involving motion, forces, and optimization. One common application is analyzing the vertical motion of objects influenced by gravity, such as a ball thrown into the air.In such scenarios, the object's height changes over time in a curved pattern, rising to a maximum point...
283
Random Variables01:09

Random Variables

18.7K
A random variable is a single numerical value that indicates the outcome of a procedure. The concept of random variables is fundamental to the probability theory and was introduced by a Russian mathematician, Pafnuty Chebyshev, in the mid-nineteenth century.
Uppercase letters such as X or Y denote a random variable. Lowercase letters like x or y denote the value of a random variable. If X is a random variable, then X is written in words, and x is given as a number.
For example, let X = the...
18.7K
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

302
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
302
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

1.3K
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bayesian semi-parametric approaches to normal/independent and elliptical distributions.

Journal of applied statistics·2026
Same author

Mathematical optimization in classification and regression trees.

Top (Berlin, Germany)·2024
Same author

On sparse ensemble methods: An application to short-term predictions of the evolution of COVID-19.

European journal of operational research·2022
Same author

Enhancing Interpretability in Factor Analysis by Means of Mathematical Optimization.

Multivariate behavioral research·2019
Same author

On Building Online Visualization Maps for News Data Streams by Means of Mathematical Optimization.

Big data·2018
Same journal

A Bayesian functional concurrent zero-inflated Dirichlet-multinomial regression model with application to infant microbiome.

Biostatistics (Oxford, England)·2026
Same journal

Towards optimal environmental policies: policy learning under arbitrary bipartite network interference.

Biostatistics (Oxford, England)·2026
Same journal

Multilevel functional quantile principal component analysis.

Biostatistics (Oxford, England)·2026
Same journal

Adaptive transfer learning for time-to-event modeling with applications in disease risk assessment.

Biostatistics (Oxford, England)·2026
Same journal

High-dimensional test for one-sided hypotheses.

Biostatistics (Oxford, England)·2026
Same journal

NBSR: a Negative Binomial Softmax Regression model for microRNA-seq data analysis.

Biostatistics (Oxford, England)·2026
See all related articles

Related Experiment Video

Updated: Mar 14, 2026

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.8K

A sparsity-controlled vector autoregressive model.

Emilio Carrizosa, Alba V Olivares-Nadal, Pepa Ramírez-Cobo

    Biostatistics (Oxford, England)
    |September 23, 2016
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces a novel sparsity-controlled Vector Autoregressive (VAR) model for multivariate time series analysis. The model offers enhanced control over sparsity, improving causal inference and prediction accuracy compared to existing methods.

    Keywords:
    CausalityMixed Integer Non Linear ProgrammingMultivariate time seriesSparse modelsVector autoregressive process

    More Related Videos

    Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness
    03:14

    Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness

    Published on: December 6, 2024

    1.3K
    A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
    10:46

    A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

    Published on: December 9, 2015

    11.2K

    Related Experiment Videos

    Last Updated: Mar 14, 2026

    Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
    04:35

    Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

    Published on: July 3, 2020

    3.8K
    Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness
    03:14

    Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness

    Published on: December 6, 2024

    1.3K
    A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
    10:46

    A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

    Published on: December 9, 2015

    11.2K

    Area of Science:

    • Statistics
    • Time Series Analysis
    • Econometrics

    Background:

    • Vector Autoregressive (VAR) models are standard for multivariate time series analysis.
    • Standard VAR models often lack sparsity, hindering the identification of joint dependencies and causalities.
    • Existing sparse VAR variants offer limited user control over sparsity dimensions.

    Purpose of the Study:

    • To propose a versatile sparsity-controlled VAR model.
    • To enable users to control different dimensions of sparsity in VAR models.
    • To facilitate visualization of potential causalities and improve prediction accuracy.

    Main Methods:

    • Developed a novel sparsity-controlled VAR model.
    • Formulated model coefficient estimation as an optimization problem.
    • Utilized standard numerical optimization routines for solving the problem.

    Main Results:

    • The proposed model allows users to control sparsity dimensions.
    • Demonstrated superior performance over greedy and Lasso approaches.
    • Achieved lower prediction errors and better sparsity on simulated and real-life data.

    Conclusions:

    • The developed sparsity-controlled VAR model offers enhanced flexibility and control.
    • It provides a valuable tool for causal inference and prediction in multivariate time series.
    • Outperforms existing methods in terms of prediction accuracy and sparsity control.