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Dynamic Tracking of Injected Mesenchymal Stem Cells after Myocardial Infarction in Rats: A Serial 7T MRI Study.

Xiuyu Chen1, Minjie Lu1, Ning Ma2

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Stem Cells International
|September 23, 2016
PubMed
Summary
This summary is machine-generated.

Micron-sized particles of iron oxide (MPIO) are unreliable for tracking mesenchymal stem cells (MSCs) long-term after heart attack. However, MSCs still improve cardiac function and reduce damage despite poor cell retention.

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Area of Science:

  • Cardiovascular Research
  • Regenerative Medicine
  • Biomedical Imaging

Background:

  • Myocardial infarction (MI) leads to adverse cardiac remodeling.
  • Mesenchymal stem cells (MSCs) show therapeutic potential for MI.
  • Tracking transplanted MSCs in vivo is crucial for understanding their efficacy.

Purpose of the Study:

  • To evaluate micron-sized particles of iron oxide (MPIO) for tracking MPIO-labeled MSCs in a rat MI model using 7T MRI.
  • To assess the impact of MSC transplantation on cardiac function and remodeling post-MI.

Main Methods:

  • MSCs dual-labeled with MPIO and CM-DiI were injected into the infarct periphery of rats 7 days post-MI.
  • 7T MRI was used to dynamically assess stem cell location, signal intensity, and cardiac function at multiple time points.
  • Histological analysis and real-time PCR were performed to evaluate cell fate, inflammation, and tissue repair.

Main Results:

  • MPIOs caused observable hypointensities on T2*-weighted MRI, indicating their presence.
  • MSCs transplantation moderated left ventricular remodeling and improved cardiac function.
  • Most iron-positive cells were identified as macrophages, and MSC survival decreased significantly over time.
  • MSC treatment increased capillary density and reduced cardiomyocyte apoptosis and fibrosis in the peri-infarct region.

Conclusions:

  • MPIOs are not a reliable marker for long-term in vivo tracking of MSC engraftment.
  • Despite limited cell retention, MSCs demonstrate significant therapeutic benefits in mitigating adverse cardiac remodeling after MI.