Related Experiment Video
Updated: Mar 14, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
Pregnancies complicated by preeclampsia and non-preeclampsia-related nephrotic range proteinuria
R A Brown1, G J Kemp2, S A Walkinshaw3
1Royal Liverpool and Broadgreen University Hospitals NHS Trust, UK.
Objective:
To examine the impact of nephrotic range proteinuria during pregnancy on renal, maternal and fetal outcomes.
Methods:
A retrospective study of pregnant women with proteinuria greater than 3 g/24 h. Outcome measures included: gestation and mode of delivery, maternal high dependency unit admission, birth weight, maternal blood pressure and proteinuria at time of last follow-up, renal biopsy.
Results:
Two hundred and sixty four pregnancies in 262 women were reviewed. Postnatal data were available in 180; of these 104 (57%) had urinary protein quantified postnatally. Sixty three (60%) were pure preeclampsia and nine (9%) super-imposed preeclampsia. Biopsy-proven renal disease was newly diagnosed in nine (9%). Sixty three per cent required caesarean section and 34% required high dependency unit admission. There were no maternal deaths. Birth weight corrected for gestation was below the fifth centile in 33%.
Conclusions:
The incidence of underlying renal pathology in this cohort is significant and highlights the importance of careful follow-up.
More Related Videos
07:38Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
Published on: May 6, 2018
09:43Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Related Concept Videos
Nephrotic Syndrome II : Assessment and Medical Management
Nephrotic Syndrome I : Introduction
Nephrotic Syndrome III : Nursing Management
Chronic Kidney Disease III: Interprofessional Care
Hormonal Regulation
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications