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Related Concept Videos

Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

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Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
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Pulmonary Embolism I: Introduction01:29

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Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
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Measurement of Blood Pressure01:17

Measurement of Blood Pressure

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Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
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Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

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Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
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Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

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Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
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Pneumothorax-II01:27

Pneumothorax-II

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Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
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Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat
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Pulmonary hypertension imitating HELLP syndrome.

Adam Morton1

  • 1QLD Diabetes Centre, Mater Health Services, Raymond Terrace, Australia.

Obstetric Medicine
|September 23, 2016
PubMed
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Pulmonary hypertension in pregnancy, often linked to connective tissue disorders, poses extreme maternal risks. Early echocardiography screening is crucial for these patients to prevent severe complications and mortality.

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Area of Science:

  • Cardiology
  • Rheumatology
  • Obstetrics

Background:

  • Connective tissue disorders (CTDs) are linked to a higher incidence of pulmonary hypertension (PH).
  • Pregnancy in women with PH carries substantial maternal mortality risks.
  • Early diagnosis and management of PH in pregnant patients with CTDs are critical.

Observation:

  • A case is presented of a woman with mixed connective tissue disease (MTC) experiencing undiagnosed pulmonary hypertension.
  • Her presentation mimicked severe preeclampsia with HELLP syndrome, characterized by microangiopathic hemolysis, thrombocytopenia, and elevated liver enzymes.
  • End-stage PH can manifest with hemolysis and thrombocytopenia, complicating diagnosis in pregnancy.

Findings:

  • Pulmonary hypertension can present with hemolysis and thrombocytopenia, mimicking HELLP syndrome in pregnant women.
  • Echocardiography is vital for excluding PH in women with CTDs before conception.
  • Extracorporeal membrane oxygenation (ECMO) may be a viable option for peripartum management of severe PH.

Implications:

  • Routine echocardiographic screening for pulmonary hypertension is recommended for all women with connective tissue disorders prior to conception.
  • Timely diagnosis and intervention can mitigate the high maternal mortality associated with PH in pregnancy.
  • Consideration of advanced life support like ECMO may be necessary for critical peripartum cases.