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Test statistic and sample size for a two-sample McNemar test
1National Cancer Institute, Division of Cancer Prevention and Control, Bethesda, Maryland 20892.
Biometrics
|June 1, 1989
Abstract:
McNemar's (1947, Psychometrika 12, 153-157) test of marginal homogeneity is generalized to a two-sample situation where the hypothesis of interest is that the marginal changes in each of two independently sampled tables are equal. This situation is especially applicable to two cohorts (a control and an intervention cohort), each measured at baseline and after the intervention on a binary outcome variable. Some assumptions often realistic in this situation simplify the calculation of sample size. The calculation of sample size in a study designed to increase utilization of breast cancer screening is demonstrated.