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Updated: Mar 14, 2026

Synthesis of Single-Crystalline Core-Shell Metal-Organic Frameworks
Published on: February 10, 2023
Total Synthesis of (±)-Kuwanol E
Valentina Iovine1,2, Irene Benni1, Rocchina Sabia1
1Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma , p.le Aldo Moro 5, 00185 Roma, Italy.
Abstract:
The total synthesis of the Diels-Alder-type adducts (±)-kuwanol E and the heptamethyl ether derivative of (±)-kuwanon Y has been accomplished via a convergent strategy involving 2'-hydroxychalcone 6 or 9 and dehydroprenylstilbene 7, in nine steps. The synthesis features, as a key step, a Lewis acid-mediated biomimetic intermolecular Diels-Alder [4+2] cycloaddition for the construction of the cyclohexene skeleton with three stereogenic centers. Notably, the endo/exo diastereoselectivity of the reaction proved to be temperature-controlled.
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