Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

19.0K
When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
19.0K
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

54.8K
Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
54.8K
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

37.2K
37.2K
Cascaded Op Amps01:16

Cascaded Op Amps

1.2K
Operational amplifiers (op-amps) are versatile electronic components that can be interconnected in a cascade - one after another in a linear sequence. This cascading is possible due to their infinite input resistance and zero output resistance, allowing them to maintain their input-output relationships even when connected in series.
In a cascaded system, each op-amp is referred to as a stage. The output of one stage drives the input of the subsequent stage. As the input signal passes through...
1.2K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.7K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.7K
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

8.3K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
8.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Warning and contextual mechanisms in the illusory truth effect.

Consciousness and cognition·2026
Same author

Causal parametric language mapping with electrical stimulation during awake neurosurgery.

Science advances·2026
Same author

The Impact of Foreign Language on Meta-Reasoning in Moral Decisions.

Journal of cognition·2026
Same author

In the Words of Others: ERP Evidence of Speaker-Specific Phonological Prediction.

Psychophysiology·2025
Same author

Suggestions for the decision making in subjective cognitive complaints.

Aging clinical and experimental research·2025
Same author

Words before pictures: the role of language in biasing visual attention.

Frontiers in psychology·2025

Related Experiment Video

Updated: Mar 14, 2026

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions
07:18

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions

Published on: October 27, 2023

3.4K

Activation cascading in sign production.

Eduardo Navarrete1, Francesca Peressotti1, Luigi Lerose2

  • 1Dipartimento di Psicologia dello Sviluppo e della Socializzazione, Università di Padova.

Journal of Experimental Psychology. Learning, Memory, and Cognition
|September 23, 2016
PubMed
Summary

This study shows that language processing involves activation spreading, even for signs not actively produced. This cascading activation speeds up sign production, similar to spoken language.

More Related Videos

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy
12:24

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

Published on: September 29, 2016

7.4K
Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation
08:00

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation

Published on: October 4, 2024

1.2K

Related Experiment Videos

Last Updated: Mar 14, 2026

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions
07:18

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions

Published on: October 27, 2023

3.4K
Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy
12:24

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

Published on: September 29, 2016

7.4K
Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation
08:00

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation

Published on: October 4, 2024

1.2K

Area of Science:

  • Psycholinguistics
  • Sign Language Linguistics
  • Cognitive Science

Background:

  • Theories of language production suggest activation spreads from semantics to lexical representations.
  • It is debated whether this 'cascading activation' occurs in sign language production.
  • Sign iconicity, the visual resemblance between a sign and its referent, may influence activation patterns.

Purpose of the Study:

  • To investigate cascading activation in sign production.
  • To determine if semantic information from non-produced signs influences production.
  • To examine the role of sign iconicity in activation spreading.

Main Methods:

  • A picture-picture interference task was used with deaf signers.
  • Participants named a target picture while ignoring a distractor picture.
  • Experiments manipulated the semantic relatedness and iconicity of target and distractor signs.

Main Results:

  • Sign production was faster when target and distractor pictures shared related signs.
  • This facilitation effect supports cascading activation in sign language.
  • Iconic signs, particularly as distractors, also led to faster responses.
  • Iconicity also facilitated performance in a simple picture-naming task.

Conclusions:

  • Cascading activation is a fundamental mechanism in both spoken and signed language processing.
  • Semantic activation spreads to representations of signs even when they are not produced.
  • Sign iconicity plays a role in modulating activation during sign production.