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Extending the Power-Law Hemolysis Model to Complex Flows
Mohammad M Faghih1, M Keith Sharp1
1Biofluid Mechanics Laboratory, Department of Mechanical Engineering, University of Louisville, Louisville, KY 40292.
Journal of Biomechanical Engineering
|September 23, 2016
Summary
This study clarifies the power-law model for predicting red blood cell damage in medical devices. It resolves inconsistencies in applying fluid stress models to complex blood flows, ensuring accuracy for shear flow conditions.
Area of Science:
- Biomedical Engineering
- Fluid Mechanics
- Hematology
Background:
- Hemolysis, or red blood cell damage, is a critical issue in blood-contacting medical devices.
- Predicting hemolysis is essential for device safety and efficacy.
- Current models, like the power-law model, face challenges when applied to complex flow conditions.
Purpose of the Study:
- To clarify the correct extension of the power-law model for hemolysis prediction in complex flows.
- To address inconsistencies in the application of scalar stress in hemolysis models.
- To ensure the power-law model maintains accuracy in the limit of pure shear flow.
Main Methods:
- Review and analysis of the power-law model for hemolysis.
- Investigation of the extension of shear stress to scalar stress (von Mises-like) in complex flows.
- Comparison of different forms of scalar stress application to identify inconsistencies.
Main Results:
- Identified inconsistencies in the application of scalar stress, with two forms varying by a factor of two.
- Proposed a unified and consistent method for extending the power-law model to complex flows.
- Demonstrated that the clarified method preserves the model's accuracy under pure shear conditions.
Conclusions:
- A consistent approach to extending the power-law model for hemolysis prediction in complex flows has been established.
- This clarification addresses a significant limitation in current hemolysis prediction models for medical devices.
- Accurate prediction of hemolysis is crucial for the development of safer and more effective blood-contacting devices.
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