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Cyclin A2 regulates erythrocyte morphology and numbers

Senthil Raja Jayapal1, Heather Yin-Kuan Ang2, Chelsia Qiuxia Wang1,3

  • 1a Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research) , Singapore , Republic of Singapore.

Cell Cycle (Georgetown, Tex.)
|September 23, 2016
PubMed
Summary

Cyclin A2 is crucial for red blood cell development. Ablating it causes larger, fewer red blood cells and defective maturation, highlighting its essential role in erythropoiesis.

Keywords:
Animal modelsBFU-E coloniesCFU-E coloniesCyclin A2CyclinsDNA damage and repairG1/S transitionHematopoiesisHowell-Jolly bodiesProtein kinasesStem cellsenucleationerythropoiesis

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