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Domestic diagnosis of newborn bilirubin levels?

M Jeffrey Maisels1

  • 1Department of Pediatrics, Beaumont Children's and Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA.

Acta Paediatrica (Oslo, Norway : 1992)
|September 23, 2016
PubMed
Abstract

No abstract available in PubMed .

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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
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