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Updated: Mar 14, 2026
Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery
Published on: September 19, 2014
Multiobjective guided priors improve the accuracy of near-infrared spectral tomography for breast imaging
Jinchao Feng1, Shudong Jiang2, Junqing Xu3
1Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, United StatesbBeijing University of Technology, College of Electronics Information and Control Engineering, Beijing 100124, China.
Abstract:
An image reconstruction regularization approach for magnetic resonance imaging-guided near-infrared spectral tomography has been developed to improve quantification of total hemoglobin (HbT) and water. By combining prior information from dynamic contrast enhanced (DCE) and diffusion weighted (DW) MR images, the absolute bias errors of HbT and water in the tumor were reduced by 22% and 18%, 21% and 6%, and 10% and 11%, compared to that in the no-prior, DCE- or DW-guided reconstructed images in three-dimensional simulations, respectively. In addition, the apparent contrast values of HbT and water were increased in patient image reconstruction from 1.4 and 1.4 (DCE) or 1.8 and 1.4 (DW) to 4.6 and 1.6.
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