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Nose and Nasal Cavity

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Updated: Mar 14, 2026

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

The Healthy Infant Nasal Transcriptome: A Benchmark Study.

Chin-Yi Chu¹, Xing Qiu², Lu Wang²

¹Division of Neonatology and Pediatric Molecular and Personalized Medicine Program, University of Rochester Medical Center, Rochester NY, USA.

Scientific Reports

|September 24, 2016

Summary

This summary is machine-generated.

Researchers developed a reliable RNA sequencing method using nasal cells from infants to study respiratory health. This approach reveals normal gene expression and identifies patterns linked to common infections in children.

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Primary Human Nasal Epithelial Cells: Biobanking in the Context of Precision Medicine

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Published on: April 22, 2022

Area of Science:

Pediatric respiratory research
Molecular biology and genomics
Infectious disease diagnostics

Background:

Resident cell responses significantly influence respiratory disease severity.
Airway sampling is challenging, especially in pediatric populations.
Understanding infant airway gene expression is crucial for diagnosing and managing respiratory illnesses.

Purpose of the Study:

To establish a reliable method for obtaining nasal epithelial cell RNA from infants for genome-wide transcriptomic analysis.
To characterize baseline gene expression in an asymptomatic infant cohort.
To identify factors influencing gene expression variability in infant airways.

Main Methods:

Nasal epithelial cells collected via inferior turbinate brushing in infants.
Gene expression interrogated using RNA-sequencing (RNA-seq) analysis.
Analysis of RNA recovery, gene expression patterns, and variability.

Main Results:

A reliable RNA recovery method was established without adverse events.
Nasal epithelial cells showed high expression of epithelial markers and resembled intrapulmonary airway cells.
Gene expression differences were most pronounced in the presence of pathogenic viruses and bacteria, with Moraxella showing robust associations.

Conclusions:

A feasible and reliable method for infant airway transcriptome interrogation via nasal epithelium sampling has been developed.
The methodology demonstrates fidelity and practicality for research.
Baseline gene expression and variation in healthy infants were described, providing a foundation for future studies.