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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cell-mediated Immune Responses01:40

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Cytotoxic T Cells-mediated Immune Response01:27

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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Related Experiment Video

Updated: Mar 14, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
13:37

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

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Surgical immune interventions for solid malignancies.

Masha Zeltsman1, Marissa Mayor1, David R Jones1

  • 1Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, USA.

American Journal of Surgery
|September 24, 2016
PubMed
Summary
This summary is machine-generated.

Regional immunotherapy for solid tumors is expanding, with increased clinical trials in cell-based and viral vector therapies. Surgical techniques enhance local delivery, and combination therapies show promise.

Keywords:
Adoptive cell therapyRegional immunotherapySurgical immunotherapy

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Area of Science:

  • Oncology
  • Immunotherapy
  • Clinical Trials

Background:

  • Solid malignancies present challenges for effective treatment.
  • Systematic review of regional immunotherapies for solid tumors.

Purpose of the Study:

  • To systematically review clinically translatable regional immunotherapeutic agents for solid malignancies.
  • To assess the landscape of regional immunotherapy delivery methods.

Main Methods:

  • Searched PubMed and ClinicalTrials.gov for relevant studies.
  • Included 116 articles after applying exclusion criteria from 334 initial publications.

Main Results:

  • Significant increase in regional cell-based and viral vector immunotherapy clinical trials in the past 5 years.
  • Development of surgical interventions for enhanced local delivery (intrapleural, intracranial, intraperitoneal, intratumoral).

Conclusions:

  • Regional immunotherapy for solid tumors is a growing field.
  • Multimodality approaches combining regional immunotherapy with other therapies are increasingly utilized.
  • Advancements in surgical techniques support localized immunotherapy delivery.