Comparison of High-Resolution MR Imaging and Digital Subtraction Angiography for the Characterization and Diagnosis
N J Lee1, M S Chung1, S C Jung2
1From the Department of Radiology and Research Institute of Radiology (N.J.L., M.S.C., S.C.J., H.S.K., C.-G.C., S.J.K., D.H.L., D.C.S.).
Background And Purpose:
High-resolution MR imaging has recently been introduced as a promising diagnostic modality in intracranial artery disease. Our aim was to compare high-resolution MR imaging with digital subtraction angiography for the characterization and diagnosis of various intracranial artery diseases.
Materials And Methods:
Thirty-seven patients who had undergone both high-resolution MR imaging and DSA for intracranial artery disease were enrolled in our study (August 2011 to April 2014). The time interval between the high-resolution MR imaging and DSA was within 1 month. The degree of stenosis and the minimal luminal diameter were independently measured by 2 observers in both DSA and high-resolution MR imaging, and the results were compared. Two observers independently diagnosed intracranial artery diseases on DSA and high-resolution MR imaging. The time interval between the diagnoses on DSA and high-resolution MR imaging was 2 weeks. Interobserver diagnostic agreement for each technique and intermodality diagnostic agreement for each observer were acquired.
Results:
High-resolution MR imaging showed moderate-to-excellent agreement (interclass correlation coefficient = 0.892-0.949; κ = 0.548-0.614) and significant correlations (R = 0.766-892) with DSA on the degree of stenosis and minimal luminal diameter. The interobserver diagnostic agreement was good for DSA (κ = 0.643) and excellent for high-resolution MR imaging (κ = 0.818). The intermodality diagnostic agreement was good (κ = 0.704) for observer 1 and moderate (κ = 0.579) for observer 2, respectively.
Conclusions:
High-resolution MR imaging may be an imaging method comparable with DSA for the characterization and diagnosis of various intracranial artery diseases.
Insights
High-resolution MR imaging demonstrates strong agreement with digital subtraction angiography for diagnosing intracranial artery diseases. This advanced MRI technique offers comparable accuracy to DSA for characterizing stenosis and luminal diameter.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Intracranial artery disease poses significant diagnostic challenges.
- High-resolution MR imaging (HR-MRI) has emerged as a promising non-invasive tool.
- Digital subtraction angiography (DSA) is a conventional gold standard for evaluating intracranial vasculature.
Purpose of the Study:
- To compare the diagnostic performance of HR-MRI against DSA.
- To assess the accuracy of HR-MRI in characterizing intracranial artery diseases.
- To evaluate interobserver and intermodality agreement for both imaging techniques.
Main Methods:
- A retrospective study included 37 patients with intracranial artery disease who underwent both HR-MRI and DSA within one month.
- Two independent observers assessed the degree of stenosis and minimal luminal diameter using both modalities.
- Interobserver and intermodality diagnostic agreement were calculated using kappa statistics and correlation coefficients.
Main Results:
- HR-MRI showed moderate-to-excellent agreement (ICC=0.892-0.949, κ=0.548-0.614) with DSA for stenosis and luminal diameter.
- Interobserver agreement was good for DSA (κ=0.643) and excellent for HR-MRI (κ=0.818).
- Intermodality agreement was good (κ=0.704) for one observer and moderate (κ=0.579) for the other.
Conclusions:
- High-resolution MR imaging is a comparable imaging method to DSA for intracranial artery disease.
- HR-MRI offers reliable characterization and diagnosis of various intracranial artery diseases.
- This suggests HR-MRI can be a valuable alternative to DSA in clinical practice.
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