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PET/MR: Yet another Tesla?

Markus Schwaiger1, Karl Kunze2, Christoph Rischpler2

  • 1Department of Nuclear Medicine, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Straße 22, 81675, Munich, Germany. markus.schwaiger@tum.de.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
|September 24, 2016
PubMed
Summary
This summary is machine-generated.

Positron Emission Tomography/Magnetic Resonance (PET/MR) offers advanced cardiac imaging by combining structural, functional, and molecular data. This integrated approach aids in characterizing cardiovascular disease phenotypes and assessing ischemic heart disease.

Keywords:
FDGMRIPETmyocardial infarctionmyocardial perfusion

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Area of Science:

  • Cardiovascular Imaging
  • Multimodality Imaging
  • Medical Physics

Background:

  • Positron Emission Tomography/Computed Tomography (PET/CT) is established; PET/MR is emerging for neurology, oncology, and cardiology.
  • Simultaneous PET/MR data acquisition integrates structural, functional, and molecular imaging for cardiovascular disease characterization.
  • Cardiovascular imaging requires comprehensive assessment of cardiac performance and disease phenotypes.

Purpose of the Study:

  • To explore the potential of PET/MR in non-invasively characterizing cardiovascular disease phenotypes.
  • To evaluate the combined capabilities of MR tissue characterization and PET tracer sensitivity for cardiac assessment.
  • To identify future applications of PET/MR in cardiology, including vascular and inflammatory conditions.

Main Methods:

  • Utilizes Magnetic Resonance (MR) techniques for tissue characterization, including Late Gadolinium Enhancement (LGE), myocardial perfusion, T1 maps, and extracellular volume estimation.
  • Employs Positron Emission Tomography (PET) tracers for high sensitivity and specificity in molecular imaging.
  • Combines simultaneous data acquisition from both PET and MR modalities.

Main Results:

  • PET/MR provides a unique platform to link various aspects of cardiac performance.
  • MR techniques offer detailed functional parameters and tissue characterization.
  • PET tracers supplement MRI by providing sensitive molecular information.

Conclusions:

  • PET/MR shows promise for comprehensive assessment of ischemic heart disease by integrating regional function, perfusion, and viability.
  • Potential future applications include unstable plaque imaging and characterization of cardiac inflammatory processes.
  • Further technical improvements and cost reduction are needed for routine clinical adoption in cardiology.