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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
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Contrast-Induced Acute Kidney Injury
Peter A McCullough1, James P Choi2, Georges A Feghali2
1Department of Internal Medicine, Division of Cardiology, Baylor University Medical Center, Dallas, Texas; Baylor Heart and Vascular Institute, Dallas, Texas; Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, Texas; The Heart Hospital Baylor Plano, Plano, Texas.
Journal of the American College of Cardiology
|September 24, 2016
Summary
Iodinated contrast used in cardiac procedures can cause contrast-induced acute kidney injury (CI-AKI), increasing risks for patients. This review covers CI-AKI
Area of Science:
- Cardiology
- Nephrology
- Radiology
Background:
- Coronary angiography and percutaneous interventions utilize iodinated intravascular contrast agents.
- Iodinated contrast media can precipitate contrast-induced acute kidney injury (CI-AKI) in at-risk patient populations.
- CI-AKI is associated with significant adverse outcomes, including renal replacement therapy, rehospitalization, and mortality.
Purpose of the Study:
- To review the epidemiology, pathophysiology, prognosis, and management of CI-AKI within the cardiac catheterization laboratory setting.
Main Methods:
- Literature review focusing on studies related to CI-AKI in cardiac catheterization.
Main Results:
- A consistent, graded risk of CI-AKI is observed with iodinated contrast use.
- The incidence and severity of CI-AKI correlate with adverse patient outcomes.
Conclusions:
- CI-AKI remains a significant concern in cardiac catheterization procedures.
- Understanding CI-AKI's risk factors, pathophysiology, and prognosis is crucial for effective management.
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