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T1 mapping in children and young adults with hypertrophic cardiomyopathy

Keyur Parekh1,2, Michael Markl3,4, Jie Deng5

  • 1Department of Medical Imaging, Ann and Robert H. Lurie Children's Hospital of Chicago, 225 East Chicago Avenue, Chicago, IL, 60611, USA. 23.keyurparekh@gmail.com.

The International Journal of Cardiovascular Imaging
|September 24, 2016
PubMed

Insights

Native T1 and extracellular volume fraction (ECV) are elevated in children and young adults with hypertrophic cardiomyopathy (HCM). These cardiac MRI measurements can help non-invasively assess HCM and fibrosis in young patients.

Area of Science:

  • Cardiovascular Imaging
  • Biomedical Engineering
  • Pediatric Cardiology

Background:

  • Hypertrophic cardiomyopathy (HCM) is a genetic heart disease characterized by left ventricular hypertrophy.
  • Accurate assessment of myocardial tissue characteristics is crucial for diagnosis and management.
  • Non-invasive imaging biomarkers are needed for early detection and monitoring in pediatric populations.

Purpose of the Study:

  • To evaluate global and segmental left ventricular (LV) native T1 and extracellular volume fraction (ECV) in pediatric and young adult HCM patients.
  • To compare these parameters with a healthy control cohort.
  • To determine the utility of native T1 and ECV as diagnostic tools for HCM in this age group.

Main Methods:

  • Cardiac magnetic resonance imaging (MRI) using a modified Look-Locker inversion recovery sequence was performed.
  • Native T1 and ECV were quantified in global and segmental LV regions before and after contrast administration.
  • Statistical comparisons were made between 21 HCM patients and 21 age-matched controls.

Main Results:

  • Mean native T1 was significantly higher in HCM patients (1020.4 ms) compared to controls (965.6 ms).
  • Hypertrophied LV segments in HCM showed elevated native T1 and ECV compared to non-hypertrophied segments.
  • A native T1 cutoff of 987 ms demonstrated high sensitivity (95%) and specificity (91%) for differentiating HCM patients from controls.

Conclusions:

  • Global and segmental native T1 are elevated in pediatric and young adult HCM patients.
  • Native T1 and ECV can serve as non-invasive biomarkers for assessing HCM and associated myocardial fibrosis in young individuals.
  • These MRI parameters show potential for improved diagnostic capabilities in pediatric hypertrophic cardiomyopathy.

Keywords:
ChildrenHypertrophic cardiomyopathyMagnetic resonance imagingT1 mapping

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