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Updated: Mar 14, 2026

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
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Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

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Left ventricular non-compaction and idiopathic dilated cardiomyopathy: the significant diagnostic value of

Fanny Tarando1,2, Damien Coisne3,2, Elena Galli1,4,2

  • 1Service de Cardiologie and CIC-IT 1414, Hôpital Pontchaillou - CHU Rennes, 2 rue Henri Le Guillou, 35000, Rennes, France.

The International Journal of Cardiovascular Imaging
|September 24, 2016
PubMed

Insights

Left ventricular non-compaction (LVNC) is difficult to distinguish from dilated cardiomyopathy (DCM). A specific mid-wall strain base-apex gradient using echocardiography can help differentiate these conditions.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Left ventricular non-compaction (LVNC) presents with abnormal trabeculations, often challenging to differentiate from dilated cardiomyopathies (DCM).
  • Accurate distinction is crucial for appropriate patient management and prognosis.

Purpose of the Study:

  • To identify novel echocardiographic tools for differentiating LVNC from DCM.
  • To evaluate the diagnostic performance of longitudinal strain characteristics.

Main Methods:

  • Compared longitudinal strain patterns in 48 LVNC patients and 45 DCM patients (derivation cohort).
  • Analyzed global and regional multi-layer LV longitudinal strain.
  • Validated findings in a separate cohort of 41 LVNC patients.

Main Results:

  • LVNC patients exhibited greater longitudinal deformation than DCM patients.
  • A mid-wall strain base-apex gradient showed 88.4% sensitivity and 66.7% specificity in distinguishing LVNC from DCM.
  • This gradient was the sole independent echocardiographic predictor in multivariable analysis.

Conclusions:

  • Longitudinal strain, particularly the base-apex gradient, is a valuable additive tool for differentiating LVNC from DCM.
  • The findings were confirmed in a validation cohort, demonstrating high sensitivity and negative predictive value.

Keywords:
Dilated cardiomyopathyEchocardiographyLeft ventricular non-compactionLongitudinal strain

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