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Age and gender effects on bone mass density variation: finite elements simulation
Abdelwahed Barkaoui1, Rabeb Ben Kahla2, Tarek Merzouki3
1Laboratoire de Mécanique Appliquée et Ingénierie (LR-MAI), Ecole Nationale d'Ingénieurs de Tunis, LR-11-ES19, Université de Tunis El Manar, 1002, Tunis, Tunisie. abdelwahed.barkaoui@ipeiem.utm.tn.
Biomechanics and Modeling in Mechanobiology
|September 24, 2016
Summary
This study models bone remodeling, revealing how age and gender impact bone density. Computational simulations highlight key cellular factors influencing these age- and gender-related bone density changes.
Area of Science:
- Biomechanics
- Computational Biology
- Cellular Biology
Background:
- Bone remodeling is a continuous process adapting bone structure to mechanical loads through osteoclast and osteoblast interactions.
- Bone cell differentiation and proliferation are influenced by local factors acting in paracrine or autocrine manners.
Purpose of the Study:
- To develop a mechanobiological finite element model coupling cellular activities and mechanical behavior.
- To investigate the effects of age and gender on bone remodeling evolution.
Main Methods:
- Computational simulations using 2D and 3D finite element models of the human proximal femur.
- Modeling coupled cellular activities and mechanical behavior to simulate bone remodeling.
Main Results:
- Identified age- and gender-related impacts on the bulk density alteration of trabecular bone.
- Computational simulations demonstrated significant effects of age and gender on bone density.
Conclusions:
- Age and gender are significant factors influencing bone remodeling and trabecular bone density.
- The study provides insights into the major cellular actors responsible for age- and gender-related bone density changes.
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