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Age and gender effects on bone mass density variation: finite elements simulation.

Abdelwahed Barkaoui1, Rabeb Ben Kahla2, Tarek Merzouki3

  • 1Laboratoire de Mécanique Appliquée et Ingénierie (LR-MAI), Ecole Nationale d'Ingénieurs de Tunis, LR-11-ES19, Université de Tunis El Manar, 1002, Tunis, Tunisie. abdelwahed.barkaoui@ipeiem.utm.tn.

Biomechanics and Modeling in Mechanobiology
|September 24, 2016
PubMed
Summary

This study models bone remodeling, revealing how age and gender impact bone density. Computational simulations highlight key cellular factors influencing these age- and gender-related bone density changes.

Keywords:
AgeBone remodelingFinite elements methodMass density

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Area of Science:

  • Biomechanics
  • Computational Biology
  • Cellular Biology

Background:

  • Bone remodeling is a continuous process adapting bone structure to mechanical loads through osteoclast and osteoblast interactions.
  • Bone cell differentiation and proliferation are influenced by local factors acting in paracrine or autocrine manners.

Purpose of the Study:

  • To develop a mechanobiological finite element model coupling cellular activities and mechanical behavior.
  • To investigate the effects of age and gender on bone remodeling evolution.

Main Methods:

  • Computational simulations using 2D and 3D finite element models of the human proximal femur.
  • Modeling coupled cellular activities and mechanical behavior to simulate bone remodeling.

Main Results:

  • Identified age- and gender-related impacts on the bulk density alteration of trabecular bone.
  • Computational simulations demonstrated significant effects of age and gender on bone density.

Conclusions:

  • Age and gender are significant factors influencing bone remodeling and trabecular bone density.
  • The study provides insights into the major cellular actors responsible for age- and gender-related bone density changes.