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Updated: Mar 14, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
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Published on: November 28, 2015

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Role of STAT3 in Genesis and Progression of Human Malignant Gliomas

Zangbéwendé Guy Ouédraogo1,2,3, Julian Biau1,2,4, Jean-Louis Kemeny1,5

  • 1Clermont Université, Université d'Auvergne, EA 7283, CREaT, BP 10448, F-63000, Clermont-Ferrand, France.

Molecular Neurobiology
|September 24, 2016
PubMed

Insights

Targeting Signal transducer and activator of transcription 3 (STAT3) in glioblastoma is crucial. This review examines STAT3

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Signal transducer and activator of transcription 3 (STAT3) is frequently activated in glioblastoma.
  • STAT3 is a recognized therapeutic target in glioblastoma and other cancers, yet no approved therapies exist.
  • STAT3 activation occurs via tyrosine 705 phosphorylation, with emerging evidence for serine 727 phosphorylation's role.

Purpose of the Study:

  • To review the role of STAT3 phosphorylation at serine 727 and tyrosine 705 in glioma.
  • To explore how these phosphorylation events contribute to glioblastoma development and immune evasion.
  • To discuss the implications for refining therapeutic strategies targeting STAT3 in glioma.

Main Methods:

  • Literature review of studies investigating STAT3 phosphorylation in glioma.
  • Analysis of canonical and non-canonical STAT3 activation pathways.
  • Examination of STAT3's involvement in glioblastoma pathogenesis and treatment resistance.

Main Results:

  • STAT3 phosphorylation at both serine 727 and tyrosine 705 is implicated in glioblastoma.
  • These modifications contribute to glial cell transformation and tumor progression.
  • STAT3 signaling pathways facilitate glioma's evasion of immune surveillance and standard therapies.

Conclusions:

  • Understanding the distinct roles of STAT3 serine 727 and tyrosine 705 phosphorylation is vital for effective glioblastoma treatment.
  • Targeting STAT3 requires nuanced strategies that consider its complex post-translational modifications.
  • Further research into STAT3 signaling is essential for developing novel, approved therapies for glioma.
Keywords:
GliomaSTAT3Serine 727Tyrosine 705

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