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Synthesis, isolation and purification of [(11)C]-choline
Marcin Szydło1, Michał Jadwiński1, Agnieszka Chmura1
1PET Diagnostics Department, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Gliwice Branch, Poland.
Contemporary Oncology (Poznan, Poland)
|September 24, 2016
Summary
Producing [11C]-choline, a PET tracer for prostate cancer, is challenging. This study details a rapid, automated method ensuring high purity for effective diagnostic imaging.
Area of Science:
- Nuclear Medicine
- Radiopharmaceutical Chemistry
Background:
- [11C]-choline is a vital PET tracer for detecting prostate cancer lesions and metastases.
- Current production methods face challenges due to lack of standardized pharmacopoeia descriptions.
- Efficient and reliable production is crucial given the short half-life of Carbon-11.
Purpose of the Study:
- To describe the technical aspects and process parameters for [11C]-choline production.
- To present quality control procedures for releasing [11C]-choline as an injectable solution.
- To validate a method for producing high-purity [11C]-choline suitable for patient administration.
Main Methods:
- Utilized an automated synthesizer for rapid production, isolation, and purification.
- Detailed specific process parameters to optimize yield and purity.
- Implemented rigorous quality control measures, including chromatographic techniques.
Main Results:
- Achieved high chemical, radiochemical, and radionuclide purity for the radiopharmaceutical.
- The automated process successfully produced sterile and pyrogen-free [11C]-choline within 20 minutes.
- The overall process yield reached up to 20%.
Conclusions:
- The described method enables efficient and safe production of high-quality [11C]-choline.
- Automated synthesis within the short half-life of Carbon-11 is feasible and effective.
- [11C]-choline PET scanning is a valuable diagnostic tool for equipped centers.