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Updated: Mar 14, 2026

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
Published on: April 7, 2023
Diabetes mellitus and cognitive impairments
Elham Saedi1, Mohammad Reza Gheini1, Firoozeh Faiz1
1Elham Saedi, Amir Alam Research Center, Department of Internal Medicine, Division of Neurology, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran 1416753955, Iran.
Abstract:
There is strong evidence that diabetes mellitus increases the risk of cognitive impairment and dementia. Insulin signaling dysregulation and small vessel disease in the base of diabetes may be important contributing factors in Alzheimer's disease and vascular dementia pathogenesis, respectively. Optimal glycemic control in type 1 diabetes and identification of diabetic risk factors and prophylactic approach in type 2 diabetes are very important in the prevention of cognitive complications. In addition, hypoglycemic attacks in children and elderly should be avoided. Anti-diabetic medications especially Insulin may have a role in the management of cognitive dysfunction and dementia but further investigation is needed to validate these findings.
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