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Podocytic infolding glomerulopathy: A case report.

Kye Won Kwon1, Hyeon Joo Jeong2, Jang Han Lee3

  • 1a Department of Pathology , Bundang Jesaeng General Hospital , Seongnam , South Korea.

Ultrastructural Pathology
|September 24, 2016
PubMed
Summary

Podocytic infolding glomerulopathy (PIG), a rare kidney disease, was identified in a Korean patient. Steroid treatment effectively reduced proteinuria, suggesting a potential therapeutic approach.

Keywords:
Glomerular basement membranemicrostructurespodocytic infoldingproteinuria

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Area of Science:

  • Nephrology
  • Pathology

Background:

  • Podocytic infolding glomerulopathy (PIG) is a rare glomerular disease characterized by specific ultrastructural abnormalities.
  • First described in 2008, PIG cases have been exclusively reported in Japan.

Observation:

  • This report details the first case of PIG diagnosed in a Korean female patient.
  • The patient presented with mild proteinuria, normal renal function, and no systemic disease.
  • Light microscopy revealed GBM bubbling, while electron microscopy showed microtubules and microspherules within thickened GBM.

Findings:

  • Immunofluorescence microscopy showed minimal mesangial IgM deposition.
  • Serologic tests were positive for antinuclear antibodies, with other autoimmune markers negative.
  • The characteristic GBM thickening and bubbly appearance were confirmed via PAMS staining.

Implications:

  • This case expands the geographic distribution of PIG beyond Japan.
  • Steroid therapy led to a significant reduction in proteinuria.
  • Further research is needed to understand the pathogenesis and optimal management of PIG.