Related Experiment Video

Updated: Mar 14, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.9K

Podocytic infolding glomerulopathy: A case report

Kye Won Kwon1, Hyeon Joo Jeong2, Jang Han Lee3

  • 1a Department of Pathology , Bundang Jesaeng General Hospital , Seongnam , South Korea.

Ultrastructural Pathology
|September 24, 2016
PubMed

Insights

Podocytic infolding glomerulopathy (PIG), a rare kidney disease, was identified in a Korean patient. Steroid treatment effectively reduced proteinuria, suggesting a potential therapeutic approach.

Area of Science:

  • Nephrology
  • Pathology

Background:

  • Podocytic infolding glomerulopathy (PIG) is a rare glomerular disease characterized by specific ultrastructural abnormalities.
  • First described in 2008, PIG cases have been exclusively reported in Japan.

Observation:

  • This report details the first case of PIG diagnosed in a Korean female patient.
  • The patient presented with mild proteinuria, normal renal function, and no systemic disease.
  • Light microscopy revealed GBM bubbling, while electron microscopy showed microtubules and microspherules within thickened GBM.

Findings:

  • Immunofluorescence microscopy showed minimal mesangial IgM deposition.
  • Serologic tests were positive for antinuclear antibodies, with other autoimmune markers negative.
  • The characteristic GBM thickening and bubbly appearance were confirmed via PAMS staining.

Implications:

  • This case expands the geographic distribution of PIG beyond Japan.
  • Steroid therapy led to a significant reduction in proteinuria.
  • Further research is needed to understand the pathogenesis and optimal management of PIG.
Keywords:
Glomerular basement membranemicrostructurespodocytic infoldingproteinuria

More Related Videos

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

5.5K
Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation06:39

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Published on: August 19, 2020

6.2K

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.6K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
821
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
294
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.5K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
876