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Updated: Mar 14, 2026

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
Timeline: Targeted Treatment of Hepatitis C Virus
1Editor, Trends in Microbiology.
Abstract:
Chronic hepatitis C virus infection can cause liver cirrhosis and cancer, and early treatment options were non-specific and could be toxic. Work aimed at elucidating the viral life cycle has led to better treatment options through the development of direct-acting antivirals, as exemplified by the work of Ralf Bartenschlager, Charles Rice, and Michael Sofia who have received the Lasker∼DeBakey Clinical Medical Research Award for their work on this effort. Key events in understanding HCV replication and development of direct-acting antivirals are shown in this Timeline.
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