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Updated: Mar 14, 2026

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY VALIDATES LAMINA CRIBROSA ANOMALY IN OPTIC DISK PIT.

Kumar Sambhav¹, Sandeep Grover, K V Chalam

¹Department of Ophthalmology, University of Florida College of Medicine, Jacksonville, Florida.

Retinal Cases & Brief Reports

|September 24, 2016

Summary

Swept Source Optical Coherence Tomography (SS-OCT) effectively identifies lamina cribrosa defects in optic disk pits. This advanced imaging confirms congenital optic disk anomalies causing vision loss.

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Last Updated: Mar 14, 2026

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Published on: August 4, 2018

Area of Science:

Ophthalmology
Medical Imaging
Anatomy

Background:

Optic disk pit is a rare congenital defect affecting the lamina cribrosa.
It can lead to vision-impairing conditions like serous macular detachment.
Conventional imaging like Spectral Domain Optical Coherence Tomography (SD-OCT) may not fully delineate lamina cribrosa anomalies.

Observation:

A case report details a 25-year-old male with sudden vision decrease in his right eye.
Fundus examination revealed optic disk pit and serous macular detachment.
En-face imaging using Swept Source Optical Coherence Tomography (SS-OCT) was performed.

Findings:

SS-OCT confirmed a defect in the lamina cribrosa corresponding to the optic disk pit.
While SD-OCT showed neurosensory detachment, it did not clearly visualize the lamina cribrosa defect.
SS-OCT provided superior resolution of the optic disk, validating the structural anomaly.

Implications:

SS-OCT is a valuable tool for diagnosing and understanding optic disk pit and associated lamina cribrosa defects.
Accurate visualization of these defects can improve diagnostic capabilities for congenital optic nerve anomalies.
Advanced OCT technology enhances the characterization of rare, visually impairing optic disk disorders.