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Published on: June 18, 2013
In-utero exposure to nelfinavir-ethyl methyl sulfone
Mira Hleyhel1, Stéphanie Goujon, Jeanne Sibiude
1aEpidemiology and Population Health Center, Institut National de la Santé et de la Recherche Médicale, INSERM U1018, Le Kremlin-Bicêtre bEpidemiology and Biostatistics, INSERM UMR1153, Sorbonne Paris Cité Research Center, Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Université Paris Descartes cFrench National Registry of Childhood Cancers, Villejuif dGynecology and Obstetrics Department, Hôpital Louis Mourier, Hôpitaux Universitaires Paris Nord Val de Seine, AP-HP, Colombes eImmunology Hematology Rhumatology Unit, Pediatric Department, Hôpital Necker-Enfants Malades AP-HP; Université Paris Descartes, Paris fHôpital Bicêtre, AP-HP; Université Paris Sud, Le Kremlin-Bicêtre, France.
Abstract:
Ethyl methyl sulfone contained in nelfinavir between 2007 and 2008 accidentally exposed embryos and fetuses to a powerful mutagen. We report data for 101 HIV-uninfected children exposed in utero included in the French prospective national cohort. The incidence of malformation was similar to that in the cohort as a whole with different drug exposures; no children had developed cancer after 9 years of follow-up.
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