Transgenerational effect of orthoaminoasotoluol in mice

Transplacental effect of orthoaminoasotoluol (OAAT) on the liver was studied in 3 generations of CBA mice. OAAT was administered to mice intragastrically at the 17, 18 and 19th day of pregnancy. A high incidence of liver tumors was observed in males (73.1% compared with 40.6% in control animals) and 34.3% in females compared to 4.6% in control animals which were the F1 descendants of treated mothers. The females of the F2 generation which were not in direct contact with OAAT developed a statistically higher, compared with the control incidence of liver tumors (24%). The liver tumor incidence in males of the F2 (20.6%) and F3 (17.8%) generations was lower than in the control group (40.5%). The liver tumor incidence in the controls was similar to that observed in F3 females (4.05%).