Related Experiment Video

Updated: Mar 14, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

19.4K

Role and therapeutic potential of CDK12 in human cancers

Rosaria Chilà1, Federica Guffanti1, Giovanna Damia1

  • 1Laboratory of Molecular Pharmacology, Oncology Department, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

Cancer Treatment Reviews
|September 24, 2016
PubMed

Insights

Cyclin-dependent kinase 12 (CDK12) plays a crucial role in gene transcription and maintaining genomic stability. This review highlights CDK12

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • Cyclin-dependent kinases (CDKs) regulate RNA polymerase II C-terminal domain phosphorylation, a key step in productive transcription.
  • Dysregulated transcription-CDKs are implicated in human cancers, with CDK9 previously being the primary focus.
  • Emerging evidence highlights the significant role of CDK12 in cellular processes and cancer development.

Purpose of the Study:

  • To review the multifaceted roles of CDK12 in transcription and RNA processing.
  • To elucidate CDK12's function in maintaining genomic stability and integrity.
  • To explore the involvement of CDK12 in tumorigenesis and its potential as a therapeutic target.

Main Methods:

  • Literature review of studies investigating CDK12 function.
  • Analysis of reported CDK12 mutations in various human cancers.
  • Examination of evidence linking CDK12 to DNA repair mechanisms and cancer pathology.

Main Results:

  • CDK12 is essential for proper transcription and RNA processing.
  • CDK12 mutations are found in numerous cancers and may lead to defective DNA repair, as observed in ovarian carcinoma.
  • CDK12's involvement in maintaining genomic stability is critical.

Conclusions:

  • CDK12 is a critical regulator of transcription and genomic integrity.
  • Mutations in CDK12 are associated with various cancers and impaired DNA repair.
  • CDK12 represents a promising novel therapeutic target in oncology.
Keywords:
CDK12DNA repairOvarian cancerTranscription

More Related Videos

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

11.9K
Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach11:11

Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach

Published on: February 21, 2019

7.9K

Related Concept Videos

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
6.1K
Inhibition of CDK Activity02:34

Inhibition of CDK Activity

5.6K
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
6.7K
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

3.0K
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
7.0K
Positive Regulator Molecules01:45

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
136.9K