Related Experiment Video

Updated: Mar 14, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.6K

Membranous Lupus Nephritis: The Same, But Different

Frank Ward1, Joanne M Bargman1

  • 1Division of Nephrology, Department of Medicine, University Health Network, Toronto, Ontario, Canada.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|September 25, 2016
PubMed

Insights

Membranous lupus nephritis (MLN) generally has a better prognosis than other lupus nephritis types but can lead to kidney failure. Current treatments focus on supportive care and various immunosuppressants, with ongoing research into optimal regimens.

Area of Science:

  • Nephrology
  • Immunology
  • Internal Medicine

Background:

  • Membranous lupus nephritis (MLN) is a kidney disease often associated with systemic lupus erythematosus.
  • While generally having a better prognosis than proliferative lupus nephritis (PLN), MLN can still progress to end-stage kidney disease.
  • Treatment involves supportive care and immunosuppression, but optimal strategies are still under investigation.

Observation:

  • Nondirected care includes renin-angiotensin-aldosterone system blockade, cardiovascular risk management, and antimalarial agents.
  • Corticosteroid monotherapy may be beneficial for some MLN patients, warranting further study.
  • Established immunosuppressants like mycophenolate, cyclophosphamide, and azathioprine may be effective in MLN, potentially reducing steroid dependence.

Findings:

  • Calcineurin inhibitors show promise for MLN treatment, with experimental data suggesting nonimmunologic antiproteinuric effects.
  • Evidence is emerging for "multitargeted therapy" in combined MLN/PLN, though long-term efficacy is unproven.
  • High-grade evidence supporting specific immunosuppression regimens for MLN remains elusive.

Implications:

  • Further research is needed to establish optimal immunosuppression protocols for MLN.
  • Calcineurin inhibitors represent a potential alternative treatment avenue for MLN.
  • Understanding the long-term efficacy of multitargeted therapies is crucial for managing combined lupus nephritis types.
Keywords:
Membranous lupus nephritis (MLN)calcineurin inhibitionclass V lupus nephritisend-stage kidney diseaseimmunosuppressionpathophysiologyrenal prognosisreviewrituximabsystemic lupus erythematosus

More Related Videos

Murine Bilateral Renal Lymphadenectomy06:20

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

130
Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

1.0K

Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
821
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
8.2K
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
294
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
8.1K
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
415