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Related Experiment Video

Updated: Jan 9, 2026

Detection of Inter-chromosomal Stable Aberrations by Multiple Fluorescence In Situ Hybridization mFISH and Spectral Karyotyping SKY in Irradiated Mice
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A specific chromosome breakpoint associated with mouse plasmacytomas.

J S Shepard, O S Pettengill, D H Wurster-Hill

    Journal of the National Cancer Institute
    |July 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Researchers studied mouse plasmacytoma chromosomes, finding a unique marker translocation. A common breakpoint on chromosome 15 was identified, suggesting its importance in plasmacytoma development.

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    Area of Science:

    • Cytogenetics
    • Cancer Biology
    • Mouse Models

    Background:

    • Mouse plasmacytomas are a valuable model for studying plasma cell cancers.
    • Chromosomal abnormalities are common in cancer development and progression.
    • Specific translocations are often associated with particular tumor types.

    Purpose of the Study:

    • To characterize the chromosomal makeup of the near-diploid mouse plasmacytoma MOPC-31C.
    • To identify unique and common chromosomal markers in this tumor.
    • To investigate the significance of chromosomal breakpoints in mouse plasmacytoma development.

    Main Methods:

    • Karyotypic analysis of uncultured MOPC-31C mouse plasmacytoma cells.
    • Chromosome banding techniques to identify specific chromosomal structures and translocations.
    • Comparison of chromosomal findings with previously studied mouse plasmacytomas.

    Main Results:

    • The MOPC-31C tumor exhibited a modal chromosome number of 44.
    • It lacked the reciprocal translocation [rcp t(12; 15)] common in other myelomas.
    • A unique reciprocal translocation, rcp t(6; 15), was identified.
    • A shared breakpoint at chromosome 15 band D3/E was observed, consistent across examined plasmacytomas.

    Conclusions:

    • The MOPC-31C plasmacytoma presents a distinct chromosomal profile.
    • The common breakpoint on chromosome 15 (D3/E) is a recurring feature in mouse plasmacytomas.
    • This conserved breakpoint is likely critical for the pathogenesis of mouse plasmacytomas.