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Corosolic acid protects hepatocytes against ethanol-induced damage by modulating mitogen-activated protein kinases

Xiaolan Guo1, Ruibing Cui1, Jianjian Zhao1

  • 1Department of Hepatology and Gastroenterology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong 250012, People's Republic of China.

European Journal of Pharmacology
|September 25, 2016
PubMed

Insights

Corosolic acid protects the liver from alcohol damage by reducing harmful reactive oxygen species (ROS) and activating autophagy. This natural compound may be a promising treatment for alcoholic liver diseases.

Area of Science:

  • Hepatology
  • Molecular Biology
  • Pharmacology

Background:

  • Ethanol-induced liver injury is linked to reactive oxygen species (ROS)/mitogen-activated protein kinase (MAPK) pathways.
  • Corosolic acid from banaba tree leaves shows potential liver protection, but its mechanism is unclear.

Purpose of the Study:

  • To investigate the protective mechanism of corosolic acid against ethanol-induced liver injury.
  • To explore corosolic acid's effects on MAPK signaling, autophagy, and related pathways.

Main Methods:

  • In vitro studies using BRL-3A and HepG2 cells, and in vivo studies using experimental rats.
  • Assessed apoptosis, ROS accumulation, TNF-α levels, MAPK signaling (p38, JNK), autophagy markers (beclin-1, LC3II/I), and AMPK activation.
  • Examined histopathological changes in rat livers.

Main Results:

  • Corosolic acid inhibited ethanol-induced apoptosis, ROS accumulation, and TNF-α levels.
  • It suppressed ethanol-activated p38 and c-Jun N-terminal kinase MAPK signaling.
  • Corosolic acid restored ethanol-suppressed autophagy via AMPK activation and improved liver histopathology.

Conclusions:

  • Corosolic acid protects the liver against ethanol-induced injury by modulating MAPK signaling and activating autophagy.
  • Corosolic acid shows promise as a therapeutic agent for alcoholic liver diseases.
Keywords:
AMPKApoptosisAutophagyCorosolic acidEthanolReactive oxygen species /MAPKs

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