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Updated: Mar 14, 2026

Efficient Method for Imaging Murine Lungs that Preserves Spatial Dynamics of Fungal Spores in the Airways
Published on: December 13, 2024
Fungal infections of the lung in children
Paolo Toma1, Alice Bertaina2, Elio Castagnola3
1Department of Imaging, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Abstract:
Fungal infections of the lungs are relatively common and potentially life-threatening conditions in immunocompromised children. The role of imaging in children with lung mycosis is to delineate the extension of pulmonary involvement, to assess response to therapy, and to monitor for adverse sequelae such as bronchiectasis and cavitation. The aim of this paper is to show imaging findings in a series of patients with fungal pneumonia from two tertiary children's hospitals, to discuss differential diagnoses and to show how imaging findings can vary depending on the host immune response.
Insights
This study reviews imaging findings in pediatric fungal pneumonia, a serious lung infection in immunocompromised children. It highlights how imaging helps assess infection extent, treatment response, and complications like bronchiectasis.
Area of Science:
- Pediatric Radiology
- Infectious Diseases
- Pulmonology
Background:
- Fungal lung infections are common and dangerous in immunocompromised children.
- Imaging plays a crucial role in managing pediatric pulmonary mycosis.
Purpose of the Study:
- To illustrate imaging findings in pediatric fungal pneumonia.
- To discuss differential diagnoses for lung mycosis in children.
- To explore how host immune response influences imaging presentation.
Main Methods:
- Retrospective review of imaging findings in pediatric patients with fungal pneumonia.
- Analysis of cases from two tertiary children's hospitals.
- Correlation of imaging features with clinical data and immune status.
Main Results:
- Demonstration of diverse imaging patterns of fungal pneumonia in children.
- Identification of key imaging features aiding differential diagnosis.
- Observation of imaging variations based on the degree of host immune compromise.
Conclusions:
- Imaging is essential for diagnosing and monitoring fungal pneumonia in immunocompromised children.
- Recognizing varied imaging manifestations is key to accurate diagnosis.
- Imaging findings correlate with host immune status, guiding patient management.
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