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Pediatric Central Neurocytoma.

Madhivanan Karthigeyan1, Kirti Gupta2, Pravin Salunke1

  • 11 Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Journal of Child Neurology
|September 25, 2016
PubMed
Summary

Central neurocytomas are rare pediatric brain tumors. This study reviews their clinicopathologic features and outcomes in children, addressing limited existing data on these neuronal tumors.

Keywords:
MIB-1 labeling indexbrain tumorcentral neurocytomaextraventricular central neurocytomapediatric

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Area of Science:

  • Neuro-oncology
  • Pediatric Pathology
  • Tumor Biology

Background:

  • Central neurocytomas are well-differentiated neuronal tumors.
  • They are uncommon in pediatric patients.
  • Limited data exists on their pediatric histologic spectrum and outcomes.

Purpose of the Study:

  • To describe the clinicopathologic characteristics of central neurocytomas in children.
  • To report the outcomes of pediatric central neurocytomas.
  • To contribute to the understanding of this rare tumor in a pediatric population.

Main Methods:

  • Retrospective review of pediatric central neurocytoma cases over a 5-year period.
  • Analysis of clinicopathologic features, including histologic characteristics and MIB-1 labeling index.
  • Evaluation of patient outcomes.

Main Results:

  • The study presents observations on the clinicopathologic spectrum of central neurocytomas in children.
  • Data on the outcomes associated with these tumors in the pediatric population is provided.
  • Anaplastic features such as high mitotic activity, microvascular proliferation, necrosis, and elevated MIB-1 index (>2-3%) are associated with aggressive behavior.

Conclusions:

  • Central neurocytomas in children exhibit a range of clinicopathologic features.
  • Understanding these features is crucial for predicting tumor behavior and patient outcomes.
  • Further research is needed to fully elucidate the behavior of these rare pediatric tumors.