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Published on: July 12, 2021
Cognitive Function and Heat Shock Protein 70 in Children With Temporal Lobe Epilepsy
Azza M Oraby1, Ehab R Abdol Raouf2, Mostafa M El-Saied2
11 Department of Pediatrics, Faculty of Medicine, Cairo University, Giza, Egypt.
Insights
Children with temporal lobe epilepsy show cognitive deficits and elevated serum heat shock protein 70. Higher heat shock protein 70 levels correlate with poorer memory and reasoning in pediatric epilepsy patients.
Area of Science:
- Neurology
- Biochemistry
Background:
- Temporal lobe epilepsy (TLE) is a common neurological disorder.
- Cognitive dysfunction is a frequent comorbidity in TLE.
- Heat shock proteins (HSPs) are involved in cellular stress responses.
Purpose of the Study:
- To investigate cognitive function in children with TLE.
- To measure serum heat shock protein 70 (HSP70) levels in these children.
- To explore the relationship between HSP70 levels, cognitive performance, and seizure control.
Main Methods:
- Cognitive function was assessed using the Stanford-Binet Intelligence Test in 30 children with TLE and 30 controls.
- Serum HSP70 levels were quantified via enzyme-linked immunosorbent assay (ELISA).
- Statistical analyses were performed to compare groups and identify correlations.
Main Results:
- Children with TLE exhibited significantly lower cognitive scores compared to controls.
- Elevated serum HSP70 levels were observed in the TLE group.
- Negative correlations were found between serum HSP70 and memory/composite scores; uncontrolled seizures were linked to lower verbal reasoning and higher HSP70.
Conclusions:
- Children with TLE experience cognitive dysfunction.
- Elevated serum HSP70 may serve as a biomarker for cellular stress in pediatric TLE.
- HSP70 levels correlate with cognitive deficits and seizure activity, suggesting a role in epilepsy pathophysiology.
Abstract:
We conducted the present study to examine cognitive function and serum heat shock protein 70 levels among children with temporal lobe epilepsy. The Stanford-Binet Intelligence Test was carried out to examine cognitive function in 30 children with temporal lobe epilepsy and 30 controls. Serum heat shock protein 70 levels were determined with an enzyme-linked immunosorbent assay. The epilepsy group had significantly lower cognitive function testing scores and significantly higher serum heat shock protein 70 levels than the control group; there were significant negative correlations between serum heat shock protein 70 levels and short-term memory and composite scores. Children with uncontrolled seizures had significantly lower verbal reasoning scores and significantly higher serum heat shock protein 70 levels than children with controlled seizures. Children with temporal lobe epilepsy have cognitive dysfunction and elevated levels of serum heat shock protein 70, which may be considered a stress biomarker.
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