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Updated: Mar 14, 2026
A Model of Chronic Nutrient Infusion in the Rat
Published on: August 14, 2013
Long- and short-term diabetes mellitus type 1 modify young and elder rat salivary glands morphology
Mariana Mirim Monteiro1, Talyta Thereza Soares D'Epiro1, Lisiane Bernardi2
1Cell and Developmental Biology Department, Institute of Biomedical Sciences, University of São Paulo, Brazil.
Objective:
In this study we performed a temporal analysis of the effects of Diabetes Mellitus on morphology and laminin deposition in salivary glands of young (2 months-old) and aging (12 months-old) male Wistar rats, using immunohistochemistry.
Materials And Methods:
The animals were divided in control and diabetic (Streptozotocin induced) groups and euthanized after short and long-term diabetes induction.
Results:
Short-term induction led to vacuolization of parotid acinar cells and increased laminin deposition in both animal ages. In young rats, no difference was observed between short or long-term diabetes regarding laminin deposition, but parotid acinar cells vacuolization was more discrete after long-term diabetes. A slight decrease of submandibular gland convoluted granular ducts was observed in young and elder diabetic animal ages. In diabetic aging rats was observed an increase of laminin content only in the parotid gland.
Conclusions:
These results suggest that some Diabetes Mellitus effects on salivary glands are not progressive over time, possibly due to the existence of adaptive mechanisms in response to chronic hyperglycemia. They also show that the duration of the disease was more relevant to the morphological effects than the age, although it is known that aging per se affects salivary gland morphology and function.
