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The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
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Tumor treating fields: a novel treatment modality and its use in brain tumors

Andreas F Hottinger1, Patricia Pacheco2, Roger Stupp1

  • 1CHUV University Hospital and Lausanne University, Departments of Clinical Neurosciences and Oncology, Lausanne, Switzerland (A.F.H., P.P.); University Hospital Zurich and University of Zurich, Department of Oncology, Zurich, Switzerland (R.S.) andreas.hottinger@chuv.ch roger.stupp@usz.ch.

Neuro-Oncology
|September 25, 2016
PubMed

Insights

Tumor Treating Fields (TTFields) show promise for brain tumors. In newly diagnosed glioblastoma, TTFields combined with temozolomide improved progression-free and overall survival in phase 3 trials.

Area of Science:

  • Oncology
  • Biophysics
  • Medical Technology

Background:

  • Tumor Treating Fields (TTFields) are a novel therapeutic modality using low-intensity electric fields at intermediate frequencies.
  • TTFields have demonstrated the ability to disrupt cell division and interfere with organelle assembly during mitosis.

Purpose of the Study:

  • To summarize preclinical data, mechanism of action, and clinical evidence for TTFields in brain tumors.
  • To review the outlook of TTFields in various cancer indications.

Main Methods:

  • Review of preclinical studies investigating TTFields' mechanism of action.
  • Analysis of randomized phase 3 clinical trial data for TTFields in glioblastoma (GBM).
  • Summary of TTFields delivery system: 4 transducer arrays with 9 insulated electrodes on the scalp, connected to a portable device.

Main Results:

  • TTFields demonstrated efficacy in a variety of tumor types.
  • Phase 3 trials in GBM showed TTFields, combined with temozolomide (TMZ) chemotherapy, prolonged progression-free survival (PFS) and overall survival (OS).

Conclusions:

  • TTFields represent a promising treatment for brain tumors, particularly GBM.
  • Further investigation into TTFields for other cancer indications is warranted.

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