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Updated: Mar 14, 2026

Co-immunoprecipitation of the Mouse Mx1 Protein with the Influenza A Virus Nucleoprotein
Published on: April 21, 2015
Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes
Maria Anastasina1, Nicolas Le May2, Andrii Bugai3
1Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki 00290, Finland; Institute of Biotechnology, University of Helsinki, 00014, Finland.
Abstract:
Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication.
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