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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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COPD: Management Using Bronchodilators and Corticosteroids01:26

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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Antiasthma Drugs: β2-Adrenoceptor Agonists01:25

Antiasthma Drugs: β2-Adrenoceptor Agonists

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Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
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Updated: Mar 14, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Exercise-induced bronchoconstriction update-2016.

John M Weiler, John D Brannan, Christopher C Randolph

    The Journal of Allergy and Clinical Immunology
    |September 26, 2016
    PubMed
    Summary
    This summary is machine-generated.

    This updated practice parameter provides current guidelines for exercise-induced bronchoconstriction (EIB). It emphasizes objective testing for diagnosis and reviews pharmaceutical and nonpharmaceutical interventions for managing EIB.

    Keywords:
    Exercise-induced bronchoconstrictiondiagnosisdifferential diagnosis and therapyexercise-induced asthmaexercise-induced bronchoconstriction pathogenesisexercise-induced bronchospasmnonpharmacologicpharmacologic

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    Area of Science:

    • Pulmonology
    • Sports Medicine

    Background:

    • The initial practice parameter for exercise-induced bronchoconstriction (EIB) was published in 2010.
    • Significant advancements in understanding EIB pathogenesis and diagnostic methods have occurred since 2010.

    Purpose of the Study:

    • To update contemporary practice guidelines for exercise-induced bronchoconstriction (EIB).
    • To incorporate new evidence and expert consensus into clinical recommendations.

    Main Methods:

    • A systematic literature review was conducted using PubMed.
    • Search terms included EIB pathogenesis, diagnosis, differential diagnosis, and therapy.
    • Supplementary literature and expert opinions were used when published data was insufficient.

    Main Results:

    • Dry powder mannitol for inhalation is FDA-approved but not available in the US.
    • Standardized exercise challenge or eucapnic voluntary hyperpnea (EVH) is recommended for suspected EIB with normal baseline pulmonary function.
    • The efficacy of nonpharmaceutical interventions like omega-3 fatty acids has been questioned.

    Conclusions:

    • The updated parameter is an evidence- and consensus-based document.
    • Recommendations reflect current understanding of EIB pathogenesis, diagnosis, and management.
    • Clinical practice guidelines for EIB have been refined based on recent scientific literature.